Err


    Low Dead Space Needles    



Syringes

Reuse and sharing of needles and syringes 

Sharing needles and syringes is less prevalent than sharing of other injection paraphernalia (Strike et al., 2010), but it is still quite common. In Scotland (Scott, 2008), 10-12% of people who inject drugs (PWID) used someone else’s syringe in the last month and 8-12% have kept their syringe for someone else to use. In addition, 65-70% of the people kept their own needles for reuse. In a prospective multicentric study in the US, Hagan et al. (2010), found that 49% of the people had used a syringe previously used by others during a study period of 6 months up to 1 year; Strike et al. (2010) found that 36% of PWID in English speaking Canada reported distributive needle sharing. In France, an estimated 170 syringes are distributed or sold per person who injects drugs, which equals less than half a syringe per person per day (INSERM, 2010). One can easily imagine that reuse (or sharing) of syringes remains very high.

In addition to "deliberate" or "knowledgeable” syringe sharing (which may be due to a lack of equipment available at a given time and place), some situations foster confusion. One can think of a festive atmosphere, or the presence of a large quantity of paraphernalia resulting in confusion about their ownership during group injection, the context of intensive use or psychoactive effects of substances...

A survey in France (Debrus, 2008) showed that the vast majority (85%) of PWID has already injected in the presence of other injectors and 45% of them have ever had doubts as to the ownership of the equipment used. Distribution of tools with different colours can allow PWID to differentiate their tools from those of others. Even if the main goal remains single use of sterile paraphernalia, reuse is rather a rule than an exception (Debrus, 2008), the colours will enable one to reuse his own material. The colours also visually support the message not to share equipment.


Preference for syringe type dans dead space

Syringes without an attached needle are sometimes preferred by PWID because these are available in all sizes (2 ml, 5 ml, etc.) and because they enable the use of different types of needle (the type of needle used depends on the injection site, vein health, the type of drug used…). Though it is important to provide the tools needed by clients, the use of these syringes should be discouraged.

One of their major disadvantages is that they have a much higher dead space or void volume, which means that they contain much more fluid once the plunger is fully depressed (Heimer & Abdala, 2000; Zule et al., 1997).This fluid can be almost entirely composed of blood due to the process of"booting”: after injection, the person pulls up the plunger to mix the last bit of drug with his/ her blood and reinject.

Even if a syringe is subsequently rinsed, in the case of (accidental) sharing, the risk of viral transmission is higher when detachable syringes are used (Bobashav & Zule, 2010, Gyarmathy et al., 2010 ; Zule & Bobashev, 2009 ; Zule et al., 2002).Indeed, both HIV and hepatitis C virus have been found present in higher numbers. They also survive for longer periods of time in high dead space (HDS) syringes and are more infectious at all times(Heimer & Abdala, 2000; Paintsil et al., 2010)



Viral contaminations due to the reuse and sharing of needles and syringes

The presence of HIV (antibodies, DNA or RNA) has been detected in 20-94% of the used syringes examined by Chitwood et al. (1990), Kaplan and Heimer (1995) and Shah et al. (1996).
When one focuses on the viability of the virus inside the syringe, that is to say, the presence of virus that has the ability to cause infection, HIV is found in higher numbers and remains alive for a longer period of time in high dead space syringes (those with detachable needles, the so called Luer syringes) than in low dead space syringes (Heimer & Abdala, 2000; Zule et al., 1997; Zule et al., 2013). In the case of (accidental) sharing, the risk of viral transmission is thus higher with these syringes.


The hepatitis C virus (HCV) is more virulent and infectious than HIV. HCV has been detected in 70% of the used syringes examined by Crofts et al. (2000). Inside syringes without an attached needle, this virus remains infectious for 63 days, while syringes with an attached needle no longer contained viable virus from the second day on (Paintsil et al., 2010). In the field, needle sharing has been confirmed as a risk factor for the transmission of hepatitis. C. Pouget and Others (2011) conducted a meta-analysis of 21 different scientific studies and found that needle sharing is associated with the transmission of hepatitis C (relative risk of 1.97).



Bluthenthal et al. (2007) found that, in general, the number of syringes distributed should cover at least 100% of the needs; less coverage increases paraphernalia sharing and therefore the risk of contamination.



Other infections and overall risks associated with needle and syringe reuse.


The reuse of unclean syringe can also induce bacterial infections with sometime serious health consequences (abscesses, endocarditis, septicaemia ...). Most of these bacteria come from the skin or saliva of PWID themselves. Fungal infections can also be transmitted when a person licks the needle before injection (Gambotti et al., 2006).

When syringes or needles are reused, the needle becomes blunt (figure 1) and can damage the skin and veins, which increases the risk of infections (Kaushik et al., 2001).





Figure 1

From the left to the right: a new syringe and a syringe that has been used 6 times

 





The reuse of unclean syringe can also induce bacterial infections with sometime serious health consequences (abscesses, endocarditis, septicaemia ...). Most of these bacteria come from the skin or saliva of PWID themselves. Fungal infections can also be transmitted when a person licks the needle before injection (Gambotti et al., 2006).



When syringes or needles are reused, the needle becomes blunt (figure 1) and can damage the skin and veins, which increases the risk of infections (Kaushik et al., 2001).



In general, even with the proper equipment and impeccable consumption hygiene, injection is never without risks. In addition to the damage that can be caused by the drugs, tablet fillers or cuttings, injection often leads to a deterioration of the venous condition. Many PWID encounter difficulties injecting, bruises or thrombosis (Cadet Taïrou et al., 2008; Salmon et al., 2009).



Recommendations

  • To reduce the risk of transmission or contamination, each injection should be made with a sterile syringe. Sterile syringes should be provided in the quantities requested by clients, without limitation.
  • Ideally, the number of syringes distributed should cover more than 100% of needs (syringes may be lost or confiscated and some PWID need more than one syringe to find a vein).
  • Do not force people to return used needles, but encourage them to do so.
  • Procedures for cleaning syringes can reduce the amount of pathogens and viruses, but are unable to completely eliminate them.
  • Provide needles and syringes in the sizes that meet the needs of clients to avoid losing contact with them, but continue to inform them about the differences and the safer options.
  • Encourage participants to use low dead space syringes.
  • Provide needle exchange services in places where they are needed and with opening hours that are adapted to the drug using context.
  • Provide general harm reduction information and services (social, legal, and health services).
  • Provide, besides needles and syringes, other paraphernalia, such as sterile cookers, filters, acid, water for injection, alcohol swabs, condoms, etc..

References


 

Bluthenthal RN, AndersonR, Flynn NM, Kral AH (2007) Higher syringe coverage is associated with lower odds of HIV risk and does not increase unsafe syringe disposal among syringe exchange program clients.Drug Alcohol Depend. 89(2-3): 214–222


Bobashev GV, Zule WA (2010) Modeling the effect of high dead-space syringes on the human immunodeficiency virus (HIV) epidemic among injecting drug users.
Addiction 105(8):1439-47


Cadet-Taïrou A, Gandilhon M, Toufik A, Evrard I. (2008) Phénomènes émergents liés aux drogues en 2006.
Huitième rapport national du dispositif TREND, OFDT. 191 


Caulkins JP, Kaplan EH, Lurie P, O'Connor T, Ahn SH (1998)
Can difficult-to-reuse syringes reduce the spread of HIV among injection drug users? (Paperback)Interface. 28 (3): 23-33


Chitwood
DD,McCoyC B ,InciardiJ A,McBrideD C ,ComerfordM,TrapidoE, H V ,PageJ B ,GriffinJ ,FletcherM A (1990)HIV Seropositivity of Needles from Shooting Galleries in South

Florida.AJPH February, 80, No. 2: 150- 152


Crofts N
,Caruana S,Bowden S,Kerger M.(2000)Minimising harm from hepatitis C virus needs better strategies.BMJ.2000 Oct 7;321(7265):899


Debrus M (2008)Impact de nouveaux outils sur les risques de l’injection. Gestion des risques liés au saignement après l’injection. Prévention des risques de partage accidentel.
www.apothicom.org/downloads/IMPACT DE NOUVEAUX OUTILS 2008.pdf


Gambotti L, Bonnet N, Imbert I, Astagneau P, Edel Y (2006).
Risk factors of systemic Candidosis among intravenous drug users. National Conference on Injecting Drug Use. 12-13 October 2006, London, England.http://www.exchangesupplies.org/conferences/NCIDU/2006_NCIDU/speakers/laetitia_gambotti.html


Gyarmathy VA, Neaigus A, Li N, Ujhelyi E, Caplinskiene I, Caplinskas S, Latkin CA (2010) Liquid Drugs and High Dead Space Syringes May Keep HIV and HCV Prevalence High –A Comparison of Hungary and Lithuania. Eur Addict Res16:220–228


Hagan H
,Pouget ER,Williams IT,Garfein RL,Strathdee SA,Hudson SM,Latka MH,Ouellet LJ. (2010) Attribution of hepatitis C virus seroconversion risk in young injection drug users in 5 US cities. JInfect Dis.201(3):378-385


Heimer R, Abdala N (2000). Viability of HIV-1 in syringes: implications for interventions among injection drug users.
Aids Read 10(7):410-417


Inserm (2010) Réduction des risques chez les usagers de drogues Synthèse et recommandations. Les éditions Inserm, Collection Expertise Collectives.


Kaplan EH
,Heimer R.(1995) HIV incidence among New Haven needle exchange participants: updated estimates from syringe tracking and testing data.J Acquir Immune Defic Syndr Hum Retrovirol.10(2):175-176


Kaushik KS, Kapila K, Praharaj AK (2011) Shooting up: the interface of microbial infections and drug abuse. Journal of Medical Microbiology. 60: 408-422


Paintsil E, He H, Peters C, Lindenbach BD, Heimer R. (2010) Survival of hepatis C virus in syringes: implications for transmission among injecting drug users. The Journal of Infectious Diseases. 202 (7) : 000-000


Pouget ER, Hagan H, Des Jarlais DC (2012) Meta-analysis of hepatitis C seroconversion in relation to shared syringes and drug preparation equipment. Addiction. 107 (6) : 1057-1065


Salmon
AM,DwyerR,JaunceyM,van BeekI, Topp L, Maher L (2009) Injecting-related injury and disease among clients of a supervised injecting facility.Drug and Alcohol Dependence. 101 (1) : 132-136


Scott J. (2008) Safety, risks and outcomes from the use of injecting paraphernalia. Scottish Government Social Research. 2008 (
www.scotland.gov.uk/socialresearch)


Shah SM, Shapshak P, Rivers JE, Stewart RV, Weatherby NL, Xin KQ, Page JB, Chitwood DD, Mash DC, Vlahov D, McCoy CB (1996) Detection of HIV-1 DNA in needle/syringes, paraphernalia, and washes from shooting galleries in Miami: a preliminary laboratory report. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 11, (3), 301-306


Strike C, Buchman DZ, Callaghan RC, Wender C, Anstice S, Lester B, Scrivo N, Luce J, Millson M (2010) Giving away used injection equipment: missed prevention message? Harm reduction journal. 7: 2


US Congress, Office of Technology Assessment, Difficult to reuse needles for the prevention of HIV infection among injection drug users. Background paper, OTA-IW-H-103 (Washington, DC: US Government Printing Office, October 1992). ISBN 0-16-038097-9


Zule WA, Bobashev G (2009) High Dead-Space Syringes and the Risk of HIV and HCV Infection among Injecting Drug Users. Drug Alcohol Depend 100(3):204-213


Zule WA
,Cross HE,Stover J,Pretorius C. (2013) Are major reductions in new HIV infections possible with people who inject drugs? The case for low dead-space syringes in highly affected countries.Int J Drug Policy.24(1):1-7


Zule WA, Desmond DP, Neff JA (2002) Syringe type and drug injector risk for HIV infection: a case study in Texas. Soc Sci Med55(7):1103-1113


Zule WA
,Ticknor-Stellato KM,Desmond DP,Vogtsberger KN. (1997) Evaluation of needle and syringe combinations.J Acquir Immune Defic Syndr Hum Retrovirol.14(3):294-295



[1]Harm Reduction Coalition Policy Statement on Auto-Disable Syringes (2010):http://www.google.fr/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&ved=0CDgQFjAB&url=http%3A%2F%2Fharmreduction.org%2Fwp-content%2Fuploads%2F2012%2F10%2Fhrc-auto-disable-policy.pdf&ei=QIrWUtvMDejQ0QXir4GADw&usg=AFQjCNHbC3Y79JSw1V7fFFCTKjL_JdZM9g&bvm=bv.59378465,d.d2kdownload of 14 Januari 2013